Lookup NU author(s): Lucy Sedlackova,
Dr Viktor Korolchuk
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© 2019 Elsevier B.V. Mitochondria are the energy producing dynamic double-membraned organelles essential for cellular and organismal survival. A multitude of intra- and extra-cellular signals involved in the regulation of energy metabolism and cell fate determination converge on mitochondria to promote or prevent cell survival by modulating mitochondrial function and structure. Mitochondrial fitness is maintained by mitophagy, a pathway of selective degradation of dysfunctional organelles. Mitophagy impairment and altered clearance results in increased levels of dysfunctional and structurally aberrant mitochondria, changes in energy production, loss of responsiveness to intra- and extra-cellular signals and ultimately cell death. The decline of mitochondrial function and homeostasis with age is reported to be central to age-related pathologies. Here we discuss the molecular mechanisms controlling mitochondrial dynamics, mitophagy and cell death signalling and how their perturbation may contribute to ageing and age-related illness.
Author(s): Sedlackova L, Korolchuk VI
Publication type: Review
Publication status: Published
Journal: Biochimica et Biophysica Acta - Molecular Cell Research
Print publication date: 01/04/2019
Online publication date: 28/12/2018
Acceptance date: 21/12/2018
ISSN (print): 0167-4889
ISSN (electronic): 1879-2596
Publisher: Elsevier B.V.