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RBMX family proteins connect the fields of nuclear RNA processing, disease and sex chromosome biology

Lookup NU author(s): Professor David Elliott, Caroline Dalgliesh, Gerald Hysenaj, Dr Ingrid Ehrmann

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Abstract

© 2019 Elsevier Ltd RBMX is a ubiquitously expressed nuclear RNA binding protein that is encoded by a gene on the X chromosome. RBMX belongs to a small protein family with additional members encoded by paralogs on the mammalian Y chromosome and other chromosomes. These RNA binding proteins are important for normal development, and also implicated in cancer and viral infection. At the molecular level RBMX family proteins contribute to splicing control, transcription and genome integrity. Establishing what endogenous genes and pathways are controlled by RBMX and its paralogs will have important implications for understanding chromosome biology, DNA repair and mammalian development. Here we review what is known about this family of RNA binding proteins, and identify important current questions about their functions.


Publication metadata

Author(s): Elliott DJ, Dalgliesh C, Hysenaj G, Ehrmann I

Publication type: Article

Publication status: Published

Journal: International Journal of Biochemistry and Cell Biology

Year: 2019

Volume: 108

Pages: 1-6

Print publication date: 01/03/2019

Online publication date: 26/12/2018

Acceptance date: 24/12/2018

ISSN (print): 1357-2725

ISSN (electronic): 1878-5875

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.biocel.2018.12.014

DOI: 10.1016/j.biocel.2018.12.014


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