Lookup NU author(s): Professor David Elliott,
Dr Ingrid Ehrmann
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© 2019 Elsevier Ltd RBMX is a ubiquitously expressed nuclear RNA binding protein that is encoded by a gene on the X chromosome. RBMX belongs to a small protein family with additional members encoded by paralogs on the mammalian Y chromosome and other chromosomes. These RNA binding proteins are important for normal development, and also implicated in cancer and viral infection. At the molecular level RBMX family proteins contribute to splicing control, transcription and genome integrity. Establishing what endogenous genes and pathways are controlled by RBMX and its paralogs will have important implications for understanding chromosome biology, DNA repair and mammalian development. Here we review what is known about this family of RNA binding proteins, and identify important current questions about their functions.
Author(s): Elliott DJ, Dalgliesh C, Hysenaj G, Ehrmann I
Publication type: Article
Publication status: Published
Journal: International Journal of Biochemistry and Cell Biology
Print publication date: 01/03/2019
Online publication date: 26/12/2018
Acceptance date: 24/12/2018
ISSN (print): 1357-2725
ISSN (electronic): 1878-5875
Publisher: Elsevier Ltd
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