Lookup NU author(s): Professor Roy Taylor
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© Royal College of Physicians 2019. All rights reserved. Starting with a hypothesis which postulated a simple explanation arising from the basic cause of type 2 diabetes, a series of studies has introduced a paradigm shift in our understanding of the condition. Gradual accumulation of fat in the liver and pancreas leads eventually to beta cell dedifferentiation and loss of specialised function. The consequent hyperglycaemia can be returned to normal by removing the excess fat from liver and pancreas. At present this can be achieved only by substantial weight loss, and a simple practical and efficacious method for this has been developed and applied in a series of studies. For those people who used to have type 2 diabetes, the state of post-diabetes can be long term provided that weight regain is avoided. The implications for personal health and for national health economics are considerable.
Author(s): Taylor R
Publication type: Review
Publication status: Published
Journal: Clinical Medicine
Online publication date: 01/01/2019
Acceptance date: 02/04/2018
ISSN (print): 1470-2118
ISSN (electronic): 1473-4893
Publisher: Royal College of Physicians
PubMed id: 30651243