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Lookup NU author(s): Dr Joanna Elson
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© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Mitochondrial DNA (mtDNA) variation has been implicated in several common complex and degenerative diseases, including cardiovascular disease. Inflammation is seen as part of many of these conditions. Mitochondria feature in inflammatory pathways and it has been suggested that mtDNA variation or released mtDNA might be important in this phenomenon. To determine if mtDNA is involved in the mechanisms leading up to cardiovascular disease, we investigated the role of these variants in seven indicators of oxidative stress and inflammation. This study was done in participants of the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) cohort, a South African bi-ethnic cohort (N = 363). We applied a variant load hypothesis, which is an alternative approach to, and moves away from the classic haplogroup association approaches, to evaluate the cumulative effect of non-synonymous mtDNA variants on measurements of serum peroxides, nitric oxide metabolites, 8-hydroxy-deoxyguanosine, thiobarbituric acid reactive substances, whole blood reduced glutathione, C-reactive protein, and tumor necrosis factor alpha. We found no significant relationships between non-synonymous mtDNA variants and the seven biochemical parameters investigated here. Non-synonymous mtDNA variants are unlikely to impact on disease in this cohort, to an appreciable or measurable extent.
Author(s): Venter M, Malan L, Elson JL, van der Westhuizen FH
Publication type: Article
Publication status: Published
Journal: Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis
Year: 2019
Volume: 30
Issue: 3
Pages: 440-447
Online publication date: 18/01/2019
Acceptance date: 31/10/2018
ISSN (print): 2470-1394
ISSN (electronic): 2470-1408
Publisher: Taylor and Francis Ltd
URL: https://doi.org/10.1080/24701394.2018.1544248
DOI: 10.1080/24701394.2018.1544248
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