Lookup NU author(s): Dr Iglika Ivanova,
Dr Catherine Park,
Dr Niall Kenneth
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Hypoxia-Inducible Factors (HIFs) play essential roles in the physiological response to low oxygen in all multicellular organisms, while their deregulation is associated with human diseases. HIF levels and activity are primarily controlled by the availability of the oxygen-sensitive HIFα subunits, which is mediated by rapid alterations to the rates of HIFα protein production and degradation. While the pathways that control HIFα degradation are understood in great detail, much less is known about the targeted control of HIFα protein synthesis and what role this has in controlling HIF activity during the hypoxic response. This review will focus on the signalling pathways and RNA binding proteins that modulate HIFα mRNA half-life and/or translation rate, and their contribution to hypoxia-associated diseases.
Author(s): Ivanova IG, Park CV, Kenneth NS
Publication type: Review
Publication status: Published
Online publication date: 01/02/2019
Acceptance date: 03/01/2019
ISSN (print): 2073-4409
ISSN (electronic): 2073-4409