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Translating the Hypoxic Response—the Role of HIF Protein Translation in the Cellular Response to Low Oxygen

Lookup NU author(s): Dr Iglika Ivanova, Dr Catherine Park, Dr Niall Kenneth

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Hypoxia-Inducible Factors (HIFs) play essential roles in the physiological response to low oxygen in all multicellular organisms, while their deregulation is associated with human diseases. HIF levels and activity are primarily controlled by the availability of the oxygen-sensitive HIFα subunits, which is mediated by rapid alterations to the rates of HIFα protein production and degradation. While the pathways that control HIFα degradation are understood in great detail, much less is known about the targeted control of HIFα protein synthesis and what role this has in controlling HIF activity during the hypoxic response. This review will focus on the signalling pathways and RNA binding proteins that modulate HIFα mRNA half-life and/or translation rate, and their contribution to hypoxia-associated diseases.


Publication metadata

Author(s): Ivanova IG, Park CV, Kenneth NS

Publication type: Review

Publication status: Published

Journal: Cells

Year: 2019

Volume: 8

Issue: 2

Online publication date: 01/02/2019

Acceptance date: 03/01/2019

ISSN (print): 2073-4409

ISSN (electronic): 2073-4409

URL: https://doi.org/10.3390/cells8020114

DOI: 10.3390/cells8020114


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