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The mTORC1-autophagy pathway is a target for senescent cell elimination

Lookup NU author(s): Dr Olena Kucheryavenko, Dr Glyn Nelson, Professor Thomas von Zglinicki, Dr Viktor Korolchuk, Dr Bernadette Carroll

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

Cellular senescence has recently been established as a key driver of organismal ageing. The state of senescence is controlled by extensive rewiring of signalling pathways, at the heart of which lies the mammalian Target of Rapamycin Complex I (mTORC1). Here we discuss recent publications aiming to establish the mechanisms by which mTORC1 drives the senescence program. In particular, we highlight our data indicating that mTORC1 can be used as a target for senescence cell elimination in vitro. Suppression of mTORC1 is known to extend lifespan of yeast, worms, flies and some mouse models and our proof-of-concept experiments suggest that it can also act by reducing senescent cell load in vivo.


Publication metadata

Author(s): Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B

Publication type: Article

Publication status: Published

Journal: Biogerontology

Year: 2019

Pages: ePub ahead of Print

Online publication date: 23/02/2019

Acceptance date: 12/02/2019

Date deposited: 25/02/2019

ISSN (print): 1389-5729

ISSN (electronic): 1573-6768

Publisher: Springer Netherlands

URL: https://doi.org/10.1007/s10522-019-09802-9

DOI: 10.1007/s10522-019-09802-9


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