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Positive anti-MOG antibodies in a patient with Sjögren's syndrome and transverse myelitis

Lookup NU author(s): Professor Fai Ng, Dr Joseph Guadagno

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Abstract

Twenty percent of patients with Sjogren’s syndrome experience associated neurological disease.Transverse myelitis (TM) frequently forms part of a neuromyelitis optica spectrum disorder associatedwith the presence of anti-aquaporin 4 (AQP4) antibodies. We report the first described case of a patientwho developed TM and the presence of a newly recognized antibody, anti-myelin oligodendrocyteprotein (MOG), who went on to develop Sjogren’s syndrome. AQP4 and MOG antibodies shouldbe tested to guide prognostically the chances of further relapse as well as the type and duration ofimmunotherapy in patients with coexisting Sjogren's syndrome and TM.


Publication metadata

Author(s): Jobling K, Ledingham D, Ng WF, Guadagno J

Publication type: Article

Publication status: Published

Journal: European Journal of Rheumatology

Year: 2019

Pages: Epub ahead of print

Online publication date: 06/11/2018

Acceptance date: 30/09/2018

ISSN (print): 2147-9720

ISSN (electronic): 2148-4279

Publisher: Medical Research and Education Association

URL: https://doi.org/10.5152/eurjrheum.2018.18041

DOI: 10.5152/eurjrheum.2018.18041

PubMed id: 30407164


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