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Lookup NU author(s): Dr Cindy LeeORCiD
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With the advancement in medical science and understanding the importance of biodistribution and pharmacokineticsof therapeutic agents, modern drug delivery research strives to utilize novel materials and fabricationtechnologies for the preparation of robust drug delivery systems to combat acute and chronic diseases. Comparedto traditional drug carriers, which could only control the release of the agents in a monotonic manner, the newdrug carriers are able to provide a precise control over the release time and the quantity of drug introducedinto the patient's body. To achieve this goal, scientists have introduced “programmed” and “on-demand” approaches.The former provides delivery systems with a sophisticated architecture to precisely tune the releaserate for a definite time period, while the latter includes systems directly controlled by an operator/practitioner,perhaps with a remote device triggering/affecting the implanted or injected drug carrier. Ideally, such devicescan determine flexible release pattern and intensify the efficacy of a therapy via controlling time, duration, dosage,and location of drug release in a predictable, repeatable, and reliablemanner. This review sheds light on thepast and current techniques available for fabricating and remotely controlling drug delivery systems and addressesthe application of new technologies (e.g. 3D printing) in this field.
Author(s): Davoodi P, Lee LY, Xu Q, Sunil V, Sun Y, Soh S, Wang CH
Publication type: Article
Publication status: Published
Journal: Advanced Drug Delivery Reviews
Year: 2018
Volume: 132
Pages: 104-138
Print publication date: 01/07/2018
Online publication date: 06/07/2018
Acceptance date: 02/07/2018
ISSN (print): 0169-409X
ISSN (electronic): 1872-8294
Publisher: Elsevier
URL: https://doi.org/10.1016/j.addr.2018.07.002
DOI: 10.1016/j.addr.2018.07.002
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