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Autophagy: 'Self-Eating' Your Way to Longevity

Lookup NU author(s): Dr Viktor Korolchuk

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Abstract

Ageing is the gradual decline in biological function both at the cellular and organismal level. One of the key characteristics of cellular ageing is the accumulation of damaged proteins and organelles which, in turn, can cause cellular toxicity and death. Autophagy is an evolutionarily conserved process that is responsible for the sequestration of damaged or surplus cytoplasmic components which are then delivered to the lysosome for degradation. This house-keeping mechanism is essential to maintain cellular homeostasis and survival, particularly during stress. A decline or loss of sensitivity/responsiveness of autophagy is intimately linked with an accelerated rate of ageing as well as many age-related diseases including neurodegeneration, cancer and metabolic disease where damage accumulation exceeds damage removal. This chapter summarises current knowledge regarding the relationship between autophagy and ageing and outlines some strategies that can be implemented to promote the anti-ageing effects of autophagy to improve human health and lifespan.


Publication metadata

Author(s): Pattison CJ, Korolchuk VI

Editor(s): J. Robin Harris and Viktor I. Korolchuk

Publication type: Book Chapter

Publication status: Published

Book Title: Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

Year: 2018

Volume: 90

Pages: 25-47

Online publication date: 19/02/2019

Acceptance date: 02/04/2018

Series Title: Subcellular Biochemistry

Publisher: Springer

Place Published: Singapore

URL: https://doi.org/10.1007/978-981-13-2835-0_2

DOI: 10.1007/978-981-13-2835-0_2

PubMed id: 30779005

Library holdings: Search Newcastle University Library for this item

ISBN: 9789811328343


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