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UK registry analysis of donor substance misuse and outcomes following pancreas transplantation

Lookup NU author(s): Dr Emily Thompson, Ellie Irwin, Dr Ibrahim Ibrahim, Dr Sam Tingle, Steven White, Professor Derek Manas, Colin Wilson

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

© 2019 The Authors. Clinical Transplantation Published by John Wiley & Sons Ltd Substance abuse is unfortunately common in organ donors. Often, these organs are declined for transplant, not only because of concerns around blood-borne virus transmission but also because of perceived poor outcomes. In kidney transplantation, previous studies have demonstrated donor smoking status significantly impacts transplant outcome, but intravenous drug use or alcohol dependence does not. This study aims to clarify these issues in pancreas transplantation. Retrospective data on all UK solid organ pancreas transplants from 1994 to 2015 were obtained from the NHSBT UK Transplant Registry. The impact of illicit drug misuse, alcohol abuse, and smoking on graft and patient survival were analyzed using Kaplan-Meier plots and a Cox regression model. A total of 1175 of the 2317 (49.5%) donors were categorized as substance misusers. Univariate survival analysis revealed no significant impact of substance misuse on 10-year graft or patient survival. Multivariate analysis confirmed substance misuse was not associated with impaired graft or patient survival. A history of donor substance misuse does not negatively impact 10-year graft or patient survival following pancreas transplantation. This is a large national registry analysis with long-term follow-up data and should therefore provide clinicians with reassurance when considering pancreas grafts from substance misuse donors.


Publication metadata

Author(s): Thompson ER, Irwin EA, Trotter P, Ibrahim IK, Tingle SJ, White SA, Manas DM, Wilson CH

Publication type: Article

Publication status: Published

Journal: Clinical Transplantation

Year: 2019

Volume: 33

Issue: 3

Print publication date: 01/03/2019

Online publication date: 19/01/2019

Acceptance date: 11/01/2019

Date deposited: 01/04/2019

ISSN (print): 0902-0063

ISSN (electronic): 1399-0012

Publisher: Blackwell Publishing Ltd

URL: https://doi.org/10.1111/ctr.13481

DOI: 10.1111/ctr.13481

PubMed id: 30659654


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