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Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

Lookup NU author(s): Professor Marloes PeetersORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

© 2018 The Royal Society of Chemistry. In this communication, we present the first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of a New Psychoactive Substance (NPS); namely, methoxphenidine (MXP) and its regioisomers. Selectivity of the MIP towards MXP is studied by analysing mixtures and an acquired street sample with High Performance Liquid Chromatography coupled to UV detection. The study demonstrates that the engineered polymers selectively extract MXP from heterogeneous samples, which makes for a very powerful diagnostic tool that can detect traces of MXP in complicated NPS samples.

Publication metadata

Author(s): Lowdon JW, Alkirkit SMO, Mewis RE, Fulton D, Banks CE, Sutcliffe OB, Peeters M

Publication type: Article

Publication status: Published

Journal: Analyst

Year: 2018

Volume: 143

Issue: 9

Pages: 2002-2007

Print publication date: 07/05/2018

Online publication date: 12/04/2018

Acceptance date: 11/04/2018

Date deposited: 15/04/2019

ISSN (print): 0003-2654

ISSN (electronic): 1364-5528

Publisher: Royal Society of Chemistry

URL: https://doi.org/10.1039/c8an00131f

DOI: 10.1039/c8an00131f

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