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Lookup NU author(s): Dr Laura Best, Professor Nicola PaveseORCiD
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© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: We will discuss the developments in TSPO PET imaging and the contribution this technique has had to understanding neuroinflammation in vivo, as well as the limitations inherent to the currently available radioligands and the potential future direction. Recent Findings: Positron emission tomography (PET) imaging targeting the translocator protein 18 kDa (TSPO) has led to major advances in understanding the pathological role played by microglia activation and neuroinflammation in a diverse range of neurodegenerative conditions. Summary: The first-generation radioligand 11 [C](R)-PK11195 has been the most widely studied and has led to considerable advancements in defining the role of neuroinflammation in neuronal degeneration and dysfunction. However, limitations including low signal-to-noise ratio and high nonspecific binding have led to the development of new TSPO-specific radioligands in an attempt to improve the quality of TSPO imaging. Unfortunately, these new radioligands have not been without their own problems, and the expected improvement in image quality has not been achieved.
Author(s): Best L, Ghadery C, Pavese N, Tai YF, Strafella AP
Publication type: Review
Publication status: Published
Journal: Current Neurology and Neuroscience Reports
Year: 2019
Volume: 19
Issue: 5
Print publication date: 01/05/2019
Online publication date: 02/04/2019
Acceptance date: 02/04/2019
ISSN (print): 1528-4042
ISSN (electronic): 1534-6293
Publisher: Current Medicine Group LLC 1
URL: https://doi.org/10.1007/s11910-019-0934-y
DOI: 10.1007/s11910-019-0934-y
PubMed id: 30941587
