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Antimicrobial properties of Cu-based bulk metallic glass composites after surface modification

Lookup NU author(s): Dr Sabrina Tardio, Professor Peter Cumpson, Professor Grant Burgess

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Abstract

© 2019 The aim of this work is to study the influence of two surface modification methods, surface grinding to change the surface roughness (from 240 to 4000 grit) and oxidation (furnace at 703 K for 5 h in air), on antibacterial activity against E. coli K12 of a Cu-based bulk metallic glass composite (BMGC). Variations of roughness obtained through grinding in both as-cast and oxidized samples had a minimal effect on antimicrobial activity. Oxidation in resulted in a multilayered structure with an outer CuO layer, followed by Cu 2 O layer and other phases at greater depths according to microscopy and energy dispersive X-ray results. This oxidation increased antimicrobial performance despite the CuO layer is poorer in copper than the Cu 55 Zr 40 Al 5 at. % bulk metallic glass composite substrate. This improvement could be attributed to microstructural differences between the layer and the substrate. The fine needle-shape structure of the crystalline oxide layer may account for the improvement since interphase boundaries could constitute easy diffusion paths for Cu ion release while the shape could trigger mechanosensitive channels that can favour and thus promote the migration of copper ions into the cell. Microscopy of the deposited bacteria revealed limited changes of the outer layer of the cells, with slight changes in morphology for the oxidized samples and this is attributed to the higher copper ion released. Minimum Inhibitory Concentration tests revealed that cell degradation takes place at copper concentrations of 222.4 mg/mL, much higher than measurements of copper ion diffusion in the as-cast samples, suggesting that lysis is not the first step in copper ion toxicity. These studies indicate that Cu 55 Zr 40 Al 5 bulk metallic glass composite shows promise as an antimicrobial material with tuned performance through surface oxidation.


Publication metadata

Author(s): Villapun VM, Tardio S, Cumpson P, Burgess JG, Dover LG, Gonzalez S

Publication type: Article

Publication status: Published

Journal: Surface and Coatings Technology

Year: 2019

Volume: 372

Pages: 111-120

Print publication date: 25/08/2019

Online publication date: 15/05/2019

Acceptance date: 12/05/2019

ISSN (print): 0257-8972

ISSN (electronic): 1879-3347

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.surfcoat.2019.05.041

DOI: 10.1016/j.surfcoat.2019.05.041


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