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Histopathological changes and antioxidant responses in common carp (Cyprinus carpio) exposed to copper nanoparticles

Lookup NU author(s): Dr Farhat Jabeen, Dr Abdul Chaudhry

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Taylor and Francis Ltd, 2019.

For re-use rights please refer to the publisher's terms and conditions.


Abstract

© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Despite the rapid increase of nanotechnology in a wide array of industrial sectors, the biosafety profile of nanomaterials remains undefined. The accelerated use of nanomaterials has increased the potential discharge of nanomaterials into the environment in different ways. The aquatic environment is mainly susceptible as it is likely to act as an ultimate sink for all contaminants. Therefore, this study assessed the toxicological impacts of waterborne engineered copper nanoparticles (Cu-NPs) on histology, lipid peroxidation (LPO), catalase (CAT), and glutathione (GSH) levels in the gills of common carp (Cyprinus carpio). Nanoparticles were characterized by XRD and SEM techniques. Before starting the sub-acute toxicity testing, 96 h LC50 of Cu-NPs for C. carpio was calculated as 4.44 mg/l. Then based on LC50, C. carpio of 40–45 g in weight were exposed to three sub-lethal doses of waterborne engineered Cu-NPs (0 or 0.5 or 1 or 1.5 mg/l) for a period of 14 days. The waterborne Cu-NPs have appeared to induce alterations in gill histology and oxidative stress parameters in a dose-dependent manner. The gill tissues showed degenerative secondary lamellae, necrotic lamella, fused lamella, necrosis of the primary and secondary lamella, edema, complete degeneration, epithelial lifting, degenerative epithelium, and hyperplasia in a dose-dependent manner. In the gill tissues, waterborne Cu-NPs caused a decreased level of CAT and elevated levels of LPO, and GSH in the fish exposed to the highest dose of 1.5 mg Cu-NPs/l of water. Our results indicate that the exposure to waterborne Cu-NPs was toxic to the aquatic organisms as shown by the oxidative stresses and histological alterations in C. carpio, a freshwater fish of good economic value.


Publication metadata

Author(s): Noureen A, Jabeen F, Tabish TA, Ali M, Iqbal R, Yaqub S, Chaudhry AS

Publication type: Article

Publication status: Published

Journal: Drug and Chemical Toxicology

Year: 2019

Pages: Epub ahead of print

Online publication date: 15/05/2019

Acceptance date: 27/03/2019

Date deposited: 03/06/2019

ISSN (print): 0148-0545

ISSN (electronic): 1525-6014

Publisher: Taylor and Francis Ltd

URL: https://doi.org/10.1080/01480545.2019.1606233

DOI: 10.1080/01480545.2019.1606233


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