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Alternative splicing in lung cancer

Lookup NU author(s): Alice Coomer, Dr Fiona Black, Dr Alastair Greystoke, Dr Jennifer Munkley, Professor David Elliott

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Abstract

© 2019 Elsevier B.V.Lung cancer has the highest mortality rate of all cancers worldwide. Lung cancer is a very heterogeneous disease that is often diagnosed at later stages which have a poor prognosis. Aberrant alternative splicing patterns found in lung cancer contribute to important cell functions. These include changes in splicing for the BCL2L1, MDM2, MDM4, NUMB and MET genes during lung tumourigenesis, to affect pathways involved in apoptosis, cell proliferation and cellular cohesion. Global analyses of RNASeq datasets suggest there may be many more potentially influential aberrant splicing events that need to be investigated in lung cancer. Changes in expression of the splicing factors that regulate alternative splicing events have also been identified in lung cancer. Of these, changes in expression of QKI, RBM4, RBM5, RBM6, RBM10 and SRSF1 proteins regulate many of the most frequently referenced aberrant splicing events in lung cancer. The expanding list of genes known to be aberrantly spliced in lung cancer along with the altered expression of splicing factors that regulate them are providing new clues as to how lung cancer develops, and how these events can be exploited for better treatment. This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm.


Publication metadata

Author(s): Coomer AO, Black F, Greystoke A, Munkley J, Elliott DJ

Publication type: Article

Publication status: Published

Journal: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Year: 2019

Pages: Epub ahead print

Online publication date: 29/05/2019

Acceptance date: 27/05/2019

ISSN (print): 1874-9399

ISSN (electronic): 1876-4320

Publisher: Elsevier

URL: https://doi.org/10.1016/j.bbagrm.2019.05.006

DOI: 10.1016/j.bbagrm.2019.05.006


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