Lookup NU author(s): Dr Hamed Mosaei Sejzi,
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© 2019 The Author(s). Transcription, the first phase of gene expression, is performed by the multi-subunit RNA polymerase (RNAP). Bacterial RNAP is a validated target for clinical antibiotics. Many natural and synthetic compounds are now known to target RNAP, inhibiting various stages of the transcription cycle. However, very few RNAP inhibitors are used clinically. A detailed knowledge of inhibitors and their mechanisms of action (MOA) is vital for the future development of efficacious antibiotics. Moreover, inhibitors of RNAP are often useful tools with which to dissect RNAP function. Here, we review the MOA of antimicrobial transcription inhibitors.
Author(s): Mosaei H, Harbottle J
Publication type: Review
Publication status: Published
Journal: Biochemical Society Transactions
Print publication date: 01/02/2019
Online publication date: 15/01/2019
Acceptance date: 15/01/2019
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press Ltd
PubMed id: 30647141