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Brain banking in low and middle-income countries: Raison D'être for the Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank Project

Lookup NU author(s): Professor Raj Kalaria

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Abstract

© 2018 Elsevier Inc.Brain banks are biorepositories of central nervous system (CNS) tissue including fixed and frozen whole brains, brain biopsies and spinal cord, as well as body fluids comprising the cerebrospinal fluid (CSF) and blood stored for research purposes. Though several independent brain banks exist in high income countries, only five low- and middle - income countries (LMIC) have brain banks. The African continent is yet to establish a formalized brain bank despite its huge human genomic diversity, ageing of her populations with concomitant increases in ageing – associated brain disorders and differential phenotypic expression and outcomes of brain disorders. Cellular and molecular clinicopathological studies are vital to shaping our understanding of the interaction between racial (genetic) and geographical (environmental) factors in the natural history and mechanisms of disease, and unravelling frameworks of diagnostic biomarkers, and new therapeutic and preventative interventions. The Ibadan Brain Ageing, Dementia And Neurodegeneration (IBADAN) Brain Bank, the first organized brain tissue biorepository in sub - Saharan Africa, is set up to accrue, process and store unique brain tissues for future research into a broad spectrum of neurological and psychiatric disorders. The potential unique discoveries and research breakthroughs will benefit people of African ancestry and other ancestral populations.


Publication metadata

Author(s): Akinyemi RO, Salami A, Akinyemi J, Ojagbemi A, Olopade F, Coker M, Farombi T, Nweke M, Arulogun O, Jegede A, Owolabi M, Kalaria RN, Ogunniyi A

Publication type: Review

Publication status: Published

Journal: Brain Research Bulletin

Year: 2019

Volume: 145

Pages: 136-141

Online publication date: 24/08/2018

Acceptance date: 21/08/2018

ISSN (print): 0361-9230

ISSN (electronic): 1873-2747

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.brainresbull.2018.08.014

DOI: 10.1016/j.brainresbull.2018.08.014

PubMed id: 30149197


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