Lookup NU author(s): Sarah Moore,
Professor Lynn Rochester,
Professor Helen Rodgers,
Professor Miles Witham,
Professor Avan Sayer
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Elsevier Ltd, 2020.
For re-use rights please refer to the publisher's terms and conditions.
BackgroundSarcopenia is a progressive and generalised skeletal muscle disorder, and a powerful predictor of adverse health outcomes. Exercise is a widely recommended treatment but consensus about the best approach is lacking.ObjectiveTo synthesise current systematic review evidence on the effectiveness of exercise in the treatment of sarcopenia to inform clinical practice.Data sourcesFive electronic databases were searched (15 November 2018): Cochrane Database of Systematic Reviews; MEDLINE without revisions; EMBASE; Scopus; and Web of Science.Study selection or eligibility criteriaSystematic reviews and meta-analyses of randomised controlled trials evaluating exercise to treat sarcopenia in adults including sarcopenic outcomes.Study appraisal and synthesis methodsReview data were extracted and quality assessed (using the AMSTAR 2) by two independent assessors. Due to a lack of eligible reviews, a narrative synthesis of the evidence was performed.ResultsTwo reviews were identified which included seven studies with 619 participants. Study exercise interventions included: resistance; mixed and whole body vibration training programmes. Review findings demonstrate limited low quality evidence of positive effects of mixed and resistance training in treating sarcopenia.LimitationsLimited eligible reviews restricted synthesis and interpretation of findings.Conclusion and implications of key findingsThere is a lack of high quality research with which to inform the treatment of sarcopenia with exercise. Further research using more precision when selecting sarcopenic populations and outcomes is required in this field. this will enable the identification of effective ways of treating sarcopenia with exercise before evidence-based clinical guidelines can be established.
Author(s): Moore SA, Hrisos N, Errington L, Rochester L, Rodgers H, Witham M, Sayer AA
Publication type: Article
Publication status: Published
Print publication date: 01/06/2020
Online publication date: 09/08/2019
Acceptance date: 05/08/2019
Date deposited: 22/08/2019
ISSN (print): 0031-9406
ISSN (electronic): 1873-1465
Publisher: Elsevier Ltd
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