Lookup NU author(s): Professor Rita Horvath
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© 2019 The AuthorsMuscle function is regulated by Ca2+, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca2+ delivery to the mitochondrial matrix via the mitochondrial Ca2+ uniporter, the pore of which is formed by mitochondrial calcium uniporter (MCU). MCU's gatekeeping and cooperative activation are controlled by MICU1. Loss-of-protein mutation in MICU1 causes a neuromuscular disease. To determine the mechanisms underlying the muscle impairments, we used MICU1 patient cells and skeletal muscle-specific MICU1 knockout mice. Both these models show a lower threshold for MCU-mediated Ca2+ uptake. Lack of MICU1 is associated with impaired mitochondrial Ca2+ uptake during excitation-contraction, aerobic metabolism impairment, muscle weakness, fatigue, and myofiber damage during physical activity. MICU1 deficit compromises mitochondrial Ca2+ uptake during sarcolemmal injury, which causes ineffective repair of the damaged myofibers. Thus, dysregulation of mitochondrial Ca2+ uptake hampers myofiber contractile function, likely through energy metabolism and membrane repair.© 2019 The AuthorsDebattisti et al. report that skeletal muscle-specific loss of mitochondrial Ca2+ uptake 1 (MICU1) in mouse impairs mitochondrial calcium signaling, energy metabolism, and membrane repair, leading to muscle weakness, fatigue, myofiber damage, and high CK levels, recapitulating the muscle symptoms of MICU1 loss in patients.
Author(s): Debattisti V, Horn A, Singh R, Seifert EL, Hogarth MW, Mazala DA, Huang KT, Horvath R, Jaiswal JK, Hajnoczky G
Publication type: Article
Publication status: Published
Journal: Cell Reports
Print publication date: 29/10/2019
Online publication date: 30/10/2019
Acceptance date: 20/09/2019
Date deposited: 04/11/2019
ISSN (print): 2211-1247
ISSN (electronic): 2211-1247
Publisher: Elsevier B.V.
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