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Haemolytic uremic syndrome: diagnosis and management

Lookup NU author(s): Professor Neil Sheerin

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

The thrombotic microangiopathies (TMAs) are a group of diseases characterised by microangiopathic haemolysis, thrombocytopenia, and thrombus formation leading to tissue injury. Traditionally, TMAs have been classified as either thrombotic thrombocytopenic purpura (TTP) or haemolytic uremic syndrome (HUS) based on the clinical presentation, with neurological involvement predominating in the former and acute kidney injury in the latter. However, as our understanding of the pathogenesis of these conditions has increased, it has become clear that this is an over-simplification; there is significant overlap in the clinical presentation of TTP and HUS, there are different forms of HUS, and TMAs can occur in other, diverse clinical scenarios. This review will discuss recent developments in the diagnosis of HUS, focusing on the different forms of HUS and how to diagnose and manage these potentially life-threatening diseases.


Publication metadata

Author(s): Glover E, Sheerin NS

Publication type: Review

Publication status: Published

Journal: F1000Research

Year: 2019

Volume: 8

Online publication date: 25/09/2019

Acceptance date: 01/09/2019

ISSN (electronic): 2046-1402

URL: https://doi.org/10.12688/f1000research.19957.1

DOI: 10.12688/f1000research.19957.1


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