Toggle Main Menu Toggle Search

Open Access padlockePrints

Graphene oxide-modified hydroxyapatite nanocomposites in biomedical applications: A review

Lookup NU author(s): Dr Daniel Frankel



This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


© 2019 University of Chemistry and Technology, Faculty of Environmental Technology. All rights reserved.Bacterial infection and cytotoxicity associated with implant materials used in medical devices are the major cause of implant failures. This review focusses upon the development of graphene oxide (GO) – hydroxyapatite (HA) nanocomposites as potential coating materials that can provide a solution to the rejection of implants. These nanocomposites combine the unique antibacterial properties of graphene oxide with the natural mineral composition of hydroxyapatite, as found in human bones and tooth enamel. They have potential antibacterial applications in the fields of orthopaedics, orthodontics and cardiovascular medicine. The methods used for preparation of HA and GO in addition to the combining of GO–HA nanocomposite are discussed. Cytotoxicity and antibacterial affects of GO and GO–HA to biological systems are examined as well as future applications in related fields.

Publication metadata

Author(s): Hashim NC, Frankel D, Nordin D

Publication type: Article

Publication status: Published

Journal: Ceramics - Silikaty

Year: 2019

Volume: 63

Issue: 4

Pages: 426-448

Online publication date: 06/08/2019

Acceptance date: 06/08/2019

Date deposited: 02/12/2019

ISSN (print): 0862-5468

ISSN (electronic): 1804-5847

Publisher: University of Chemistry and Technology, Faculty of Environmental Technology


DOI: 10.13168/cs.2019.0040


Altmetrics provided by Altmetric


Find at Newcastle University icon    Link to this publication