Lookup NU author(s): Dr Richard Dodds
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
We thank López-Campos and colleagues for their interest in our paper.1 As they state, we used the grip strength cutpoints from the FNIH Sarcopenia Project of <16 kg in women and <26 kg in men, which were derived by pooling data from nine large cohort studies.2 In sensitivity analysis, we applied the cut-points of <20 kg in women and <30 kg in men as developed using data from the InCHIANTI study3 and subsequently included in the EWGSOP consensus paper.4 We found that this led to an additional 21 participants being classified as having sarcopenia at baseline: using these cut-points would therefore increase the prevalence of sarcopenia in our sample from 21% to 24%. We agree with López-Campos and colleagues that there is a need to consider cut-points for grip strength in specific regions such as Latin America.5 Incident sarcopenia was not a rare outcome in our study, affecting 10.9% of those at risk (33 of 302 participants). We therefore acknowledge that the use of logistic regression could have led to the associations between predictors such as low BMI and incident sarcopenia being overestimated. However, when we repeated our incident sarcopenia analyses using Poisson regression, the results were similar to those shown in Table 2 of our paper.6 For example, we found that those with BMI 25 or above had a five-times lower risk of developing incident sarcopenia compared with those with BMI below 18.5 [RR 0.2 (95% CI: 0.05, 0.82)].
Author(s): Dodds RM
Publication type: Letter
Publication status: Published
Journal: JCSM Rapid Communications
Online publication date: 13/12/2019
Acceptance date: 07/01/2019
ISSN (electronic): 2617-1619