Lookup NU author(s): Dr Anastasia Hepburn,
Dr Cole Sims,
Dr Rakesh Heer
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
One of the key issues hampering the development of effective treatments for prostate cancer is the lack of suitable, tractable, and patient-specific in vitro models that accurately recapitulate this disease. In this review, we address the challenges of using primary cultures and patient-derived xenografts to study prostate cancer. We describe emerging approaches using primary prostate epithelial cells and prostate organoids and their genetic manipulation for disease modelling. Furthermore, the use of human prostate-derived induced pluripotent stem cells (iPSCs) is highlighted as a promising complimentary approach. Finally, we discuss the manipulation of iPSCs to generate 'avatars' for drug disease testing. Specifically, we describe how a conceptual advance through the creation of living biobanks of "genetically engineered cancers" that contain patient-specific driver mutations hold promise for personalised medicine.
Author(s): Hepburn AC, Sims CHC, Buskin A, Heer R
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Online publication date: 30/01/2020
Acceptance date: 28/01/2020
ISSN (print): 1661-6596
ISSN (electronic): 1422-0067
Publisher: NLM (Medline)
PubMed id: 32019175