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Lookup NU author(s): Professor Jordi Diaz Manera
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2019 Duchateau et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Objective Mutations in CD59 cause CIDP-like polyneuropathy in children with inherited chronic hemolysis. We hypothesized that mutations in CD59 might be found in a subset of sporadic CIDP patients. Methods 35 patients from two centers, fulfilling the EFNS/PNS diagnostic criteria for CIDP were included. CD59 coding region was amplified by PCR and Sanger sequenced. Results One rare variant was detected in a patient which resulted in a synonymous change and predicted to be neutral. Pathogenic variants were absent in our cohort. Interpretation Our pilot study suggests that mutations in CD59 are absent in adult-onset sporadic CIDP.
Author(s): Duchateau L, Martin-Aguilar L, Lleixa C, Cortese A, Dols-Icardo O, Cervera-Carles L, Pascual-Goni E, Diaz-Manera J, Callegari I, Franciotta D, Rojas-Garcia R, Illa I, Clarimon J, Querol L
Publication type: Article
Publication status: Published
Journal: PLoS ONE
Online publication date: 22/02/2019
Acceptance date: 06/02/2019
Date deposited: 27/02/2020
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
PubMed id: 30794663
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