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Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity

Lookup NU author(s): Dr Abhishek Banerjee

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Abstract

© 2015 Elsevier Ltd. Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understanding of the roles of preNMDARs in experience-dependent synaptic and circuit-specific computation. In this review we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing. PreNMDARs regulate synapse-specific neurotransmitter release and synaptic plasticity.PreNMDARs often enhance neurotransmission at specific rates of presynaptic neuron firing.The expression of preNMDARs is developmentally regulated and influenced by sensory experience.PreNMDARs are predominantly localized at presynaptic boutons.The NMDAR subunits and downstream signaling cascades associated with preNMDARs are often distinct from postsynaptic NMDARs.Astrocytes regulate preNMDAR-mediated plasticity and neurotransmission.PreNMDAR function is disrupted in several neurological disorders and promises to be an important therapeutic target.


Publication metadata

Author(s): Banerjee A, Larsen RS, Philpot BD, Paulsen O

Publication type: Review

Publication status: Published

Journal: Trends in Neurosciences

Year: 2016

Volume: 39

Issue: 1

Pages: 26-39

Print publication date: 01/01/2016

Online publication date: 23/12/2015

Acceptance date: 01/01/1900

ISSN (print): 0166-2236

ISSN (electronic): 1878-108X

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.tins.2015.11.001

DOI: 10.1016/j.tins.2015.11.001

PubMed id: 26726120


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