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Lookup NU author(s): Professor Nicola PaveseORCiD
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© 2020 International Parkinson and Movement Disorder Society. Background: Previous molecular imaging studies comparing dopamine function in vivo between early-onset PD and late-onset PD patients have shown contradictory results, presumably attributable to the aging-related decline in nigrostriatal function. Objectives: (1) To investigate baseline dopamine transporter availability in early-onset PD (<55 years) and late-onset PD (>70 years) patients, z-scores values of putamen and caudate [123I]-ioflupane uptake were calculated using the respective age-matched controls in order to correct for early presynaptic compensatory mechanisms and age-related dopamine neuron loss; (2) to examine the associations of such baseline single-photon emission computed tomography measures with the emergence of late-disease motor complications. Methods: In this retrospective study, 105 de novo PD patients who underwent [123I]-ioflupane single-photon emission computed tomography at time of diagnosis were divided into three tertile groups according to age at disease onset (35 early-onset PD and 40 late-onset PD patients). Z-scores were compared between the two groups, and their predictive power for motor complications (during a mean follow-up of 7 years) was evaluated using Cox proportional hazard models. Results: Despite a less-severe motor phenotype, early-onset PD patients exhibited more reduced [123I]-ioflupane binding in the putamen and had a higher and earlier risk for developing motor complications than those with late-onset PD. Lower [123I]-Ioflupane uptake in the putamen and caudate increased the risk of motor complications. Conclusions: Our findings indicate that a lower dopamine transporter binding in early-onset PD predicts the later development of motor complications, but it is not related to severity of motor symptoms, suggesting age-related differences in striatal compensatory mechanisms in PD. © 2020 International Parkinson and Movement Disorder Society.
Author(s): Palermo G, Giannoni S, Frosini D, Morganti R, Volterrani D, Bonuccelli U, Pavese N, Ceravolo R
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Year: 2020
Volume: 35
Issue: 6
Pages: 1028-1036
Print publication date: 01/06/2020
Online publication date: 10/03/2020
Acceptance date: 07/02/2020
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/mds.28008
DOI: 10.1002/mds.28008
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