Toggle Main Menu Toggle Search

Open Access padlockePrints

Mitochondrial Diseases: Hope for the Future

Lookup NU author(s): Dr Oliver Russell, Dr Grainne Gorman, Professor Robert Lightowlers, Professor Doug Turnbull

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

© 2020Russell et al. review recent progress in the varied approaches to treat and prevent mitochondrial disease, including small-molecule-based approaches to improve mitochondrial function or turnover, manipulation of the mitochondrial genome, and mitochondrial replacement therapy.© 2020Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum of mutations in genes encoded by either the nuclear or the mitochondrial genome. Treatments for mitochondrial diseases are currently focused on symptomatic management rather than improving the biochemical defect caused by a particular mutation. This review focuses on the latest advances in the development of treatments for mitochondrial disease, both small molecules and gene therapies, as well as methods to prevent transmission of mitochondrial disease through the germline.


Publication metadata

Author(s): Russell OM, Gorman GS, Lightowlers RN, Turnbull DM

Publication type: Review

Publication status: Published

Journal: Cell

Year: 2020

Volume: 181

Issue: 1

Pages: 168-188

Print publication date: 02/04/2020

Online publication date: 26/03/2020

Acceptance date: 01/01/1900

ISSN (print): 0092-8674

ISSN (electronic): 1097-4172

Publisher: Cell Press

URL: https://doi.org/10.1016/j.cell.2020.02.051

DOI: 10.1016/j.cell.2020.02.051


Actions

Find at Newcastle University icon    Link to this publication


Share