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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Lookup NU author(s): Dr Rachel Queen, Dr Darin Zerti

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Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

Publication metadata

Author(s): Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL, Banovich NE, Barbry P, Brazma A, Collin J, Desai TJ, Duong TE, Eickelberg O, Falk C, Farzan M, Glass I, Gupta RK, Haniffa M, Horvath P, Hubner N, Hung D, Kaminski N, Krasnow M, Kropski JA, Kuhnemund M, Lako M, Lee H, Leroy S, Linnarson S, Lundeberg J, Meyer KB, Miao Z, Misharin AV, Nawijn MC, Nikolic MZ, Noseda M, Ordovas-Montanes J, Oudit GY, Pe'er D, Powell J, Quake S, Rajagopal J, Tata PR, Rawlins EL, Regev A, Reyfman PA, Rozenblatt-Rosen O, Saeb-Parsy K, Samakovlis C, Schiller HB, Schultze JL, Seibold MA, Seidman CE, Seidman JG, Shalek AK, Shepherd D, Spence J, Spira A, Sun X, Teichmann SA, Theis FJ, Tsankov AM, Vallier L, van den Berge M, Whitsett J, Xavier R, Xu Y, Zaragosi L-E, Zerti D, Zhang H, Zhang K, Rojas M, Figueiredo F

Publication type: Article

Publication status: Published

Journal: Nature Medicine

Year: 2020

Volume: 26

Pages: 681-687

Online publication date: 23/04/2020

Acceptance date: 31/03/2020

ISSN (print): 1078-8956

ISSN (electronic): 1546-170X

Publisher: Nature Research

URL: https://doi.org/10.1038/s41591-020-0868-6

DOI: 10.1038/s41591-020-0868-6

PubMed id: 32327758

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