Browse by author
Lookup NU author(s): Professor Mark Walker, Dr Ibrahim Ibrahim, Dr Muthu Jayapaul, Dorothy Carman, Charlotte Ryan, Kevin Short, Dr David Richardson, Dr Sheila Patel
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and <0.05). In the view of previous evidence linking plasma GGT concentration to the level of systemic oxidative stress, our findings suggest a role of oxidative stress in subclinical arterial damage and in prehypertension, even in healthy subjects free of cardiometabolic risk. Arterial organ damage may represent the link between GGT and hypertension.
Author(s): Kozakova M, Gastaldelli A, Morizzo C, Hojlund K, Nilssson PM, Ferrannini E, Heine RJ, Dekker J, de Rooij S, Nijpels G, Boorsma W, Kok A, Mitrakou A, Tournis S, Kyriakopoulou K, Thomakos P, Lalic N, Lalic K, Jotic A, Lukic L, Civcic M, Nolan J, Yeow TP, Murphy M, DeLong C, Neary G, Colgan MP, Hatunic M, Gaffney P, Boran G, Konrad T, Bohles H, Fuellert S, Baer F, Zuchhold H, Golay A, Bobbioni EH, Barthassat V, Makoundou V, Lehmann TNO, Merminod T, Petrie (now Dundee) JR, Perry C, Neary F, MacDougall C, Shields K, Malcolm L, Laakso M, Salmenniemi U, Aura A, Raisanen R, Ruotsalainen U, Sistonen T, Laitinen M, Saloranta H, Coppack SW, McIntosh N, Ross J, Pettersson L, Khadobaksh P, Balkau B, Mhamdi L, Guillanneuf MT, Laville M, Bonnet F, Brac de la Perriere A, Louche-Pelissier C, Maitrepierre C, Peyrat J, Beltran S, Serusclat A, Gabriel R, Sanchez EM, Carraro R, Friera A, Novella B, Nilssone P, Persson M, Ostling G, Melander O, Burri P, Piatti PM, Monti LD, Setola E, Galluccio E, Minicucci F, Colleluori A, Walker M, Ibrahim IM, Jayapaul M, Carman D, Ryan C, Short K, McGrady Y, Richardson D, Patel S, Beck-Nielsen H, Staehr P, Hojlundd K, Vestergaard V, Olsen C, Hansen L, Bolli GB, Porcellati F, Fanelli C, Lucidi P, Calcinaro F, Saturni A, Ferranninia E, Natali A, Muscelli E, Pinnola S, Kozakovaa M, Hills SA, Landucci L, Mota L, Gastaldelli A, Ciociaro D, Mari A, Pacini G, Cavaggion C, Mingrone G, Guidone C, Favuzzi A, Di Rocco P, Anderwald C, Bischof M, Promintzer M, Krebs M, Mandl M, Hofer A, Luger A, Waldhausl W, Roden M, Palombo C
Publication type: Article
Publication status: Published
Journal: Journal of Human Hypertension
Year: 2021
Volume: 35
Pages: 334-342
Print publication date: 01/04/2021
Online publication date: 29/04/2020
Acceptance date: 31/03/2020
ISSN (print): 0950-9240
ISSN (electronic): 1476-5527
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41371-020-0337-1
DOI: 10.1038/s41371-020-0337-1
Altmetrics provided by Altmetric
