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Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome

Lookup NU author(s): Dr Sergey MelnikovORCiD

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Abstract

© 2016Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here, we report a 3.25-Å resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A–ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A–ribosome association.

Publication metadata

Author(s): Melnikov S, Mailliot J, Shin B-S, Rigger L, Yusupova G, Micura R, Dever TE, Yusupov M

Publication type: Article

Publication status: Published

Journal: Journal of Molecular Biology

Year: 2016

Volume: 428

Issue: 18

Pages: 3570-3576

Print publication date: 11/09/2016

Online publication date: 16/05/2016

Acceptance date: 07/05/2016

ISSN (print): 0022-2836

ISSN (electronic): 1089-8638

Publisher: Academic Press

URL: https://doi.org/10.1016/j.jmb.2016.05.011

DOI: 10.1016/j.jmb.2016.05.011

PubMed id: 27196944

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