Lookup NU author(s): Dr Jérémie Nsengimana
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© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict benefit from adjuvant interferon. To better understand the biological processes involved, clinicopathological factors associated with ulceration were determined in 1804 patients. From this cohort, 348 primary tumor blocks were sampled to generate gene expression data using a 502-gene cancer panel and 195 blocks were used for immunohistochemistry to detect macrophage infiltration and vessel density. Gene expression results were validated using a whole genome array in two independent sample sets. Ulceration of primary melanomas was associated with more proliferative tumors, tumor vessel invasion, and increased microvessel density. Infiltration of tumors with greater number of macrophages and gene expression pathways associated with wound healing and up-regulation of pro-inflammatory cytokines suggests that ulceration is associated with tumor-related inflammation. The relative benefit from interferon reported in patients with ulcerated tumors may reflect modification of signaling pathways involved in inflammation.
Author(s): Jewell R, Elliott F, Laye J, Nsengimana J, Davies J, Walker C, Conway C, Mitra A, Harland M, Cook MG, Boon A, Storr S, Safuan S, Martin SG, Jirstrom K, Olsson H, Ingvar C, Lauss M, Bishop T, Jonsson G, Newton-Bishop J
Publication type: Article
Publication status: Published
Journal: Pigment Cell and Melanoma Research
Print publication date: 01/01/2015
Online publication date: 15/09/2014
Acceptance date: 08/09/2014
ISSN (print): 1755-1471
ISSN (electronic): 1755-148X
Publisher: Blackwell Publishing Ltd
PubMed id: 25220403
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