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The effect of 1,3-butanediol on cycling time-trial performance

Lookup NU author(s): Dr Deb DulsonORCiD

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Abstract

© 2019 Human Kinetics, Inc.This study investigated the effect of the racemic β-hydroxybutyrate (βHB) precursor, R,S-1,3-butanediol (BD), on time-trial (TT) performance and tolerability. A repeated-measures, randomized, crossover study was conducted in nine trained male cyclists (age, 26.7 ± 5.2 years; body mass, 69.6 ± 8.4 kg; height, 1.82 ± 0.09 m; body mass index, 21.2 ± 1.5 kg/m2; VO2peak, 63.9 ± 2.5 ml·kg-1·min-1; Wmax, 389.3 ± 50.4 W). Participants ingested 0.35 g/kg of BD or placebo 30 min before and 60 min during 85 min of steady-state exercise, which preceded a ~25- to 35-min TT (i.e., 7 kJ/kg). The ingestion of BD increased blood D-βHB concentration throughout exercise (0.44-0.79 mmol/L) compared with placebo (0.11-0.16 mmol/L; all p < .001), which peaked 1 hr following the TT (1.38 ± 0.35 vs. 0.34 ± 0.24 mmol/L; p < .001). Serum glucose and blood lactate concentrations were not different between trials (all p > .05). BD ingestion increased oxygen consumption and carbon dioxide production after 20 min of steady-state exercise (p = .002 and p = .032, respectively); however, no further effects on cardiorespiratory parameters were observed. Within the BD trial, moderate to severe gastrointestinal symptoms were reported in five participants, and low levels of dizziness, nausea, and euphoria were reported in two participants. However, this had no effect on TT duration (placebo, 28.5 ± 3.6 min; BD, 28.7 ± 3.2 min; p = .62) and average power output (placebo, 290.1 ± 53.7 W; BD, 286.4 ± 45.9 W; p = .50). These results suggest that BD has no benefit for endurance performance.

Publication metadata

Author(s): Shaw DM, Merien F, Braakhuis A, Plews D, Laursen P, Dulson DK

Publication type: Article

Publication status: Published

Journal: International Journal of Sport Nutrition and Exercise Metabolism

Year: 2019

Volume: 29

Issue: 5

Pages: 466-473

Online publication date: 01/05/2016

Acceptance date: 02/04/2016

ISSN (print): 1526-484X

ISSN (electronic): 1543-2742

Publisher: Human Kinetics Publishers Inc.

URL: https://doi.org/10.1123/ijsnem.2018-0284

DOI: 10.1123/ijsnem.2018-0284

PubMed id: 30632425

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