Lookup NU author(s): Dr Ana Viñuela
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America.To elucidate the proteomic features of aging in plasma, the subproteome targeted by the SOMAscan assay was profiled in blood samples from 202 females from the TwinsUK cohort. Findings were replicated in 677 independent individuals from the AddNeuroMed, Alzheimer's Research UK, and Dementia Case Registry cohorts. Results were further validated using RNAseq data from whole blood in TwinsUK and the most significant proteins were tested for association with aging-related phenotypes after adjustment for age. Eleven proteins were associated with chronological age and were replicated at protein level in an independent population. These were further investigated at gene expression level in 384 females from the TwinsUK cohort. The two most strongly associated proteins were chordin-like protein 1 (meta-analysis β [SE] = 0.013 [0.001], p = 3.66 × 10-46) and pleiotrophin (0.012 [0.005], p = 3.88 × 10-41). Chordin-like protein 1 was also significantly correlated with birthweight (0.06 [0.02], p = 0.005) and with the individual Framingham 10-years cardiovascular risk scores in TwinsUK (0.71 [0.18], p = 9.9 × 10-5). Pleiotrophin is a secreted growth factor with a plethora of functions in multiple tissues and known to be a marker for cardiovascular risk and osteoporosis. Our study highlights the importance of proteomics to identify some molecular mechanisms involved in human health and aging.
Author(s): Menni C, Kiddle SJ, Mangino M, Vinuela A, Psatha M, Steves C, Sattlecker M, Buil A, Newhouse S, Nelson S, Williams S, Voyle N, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Spector TD, Dobson R, Valdes AM
Publication type: Article
Publication status: Published
Journal: Journals of Gerontology: Series A - Biological Sciences and Medical Sciences
Print publication date: 01/07/2021
Online publication date: 14/08/2014
Acceptance date: 24/06/2014
Date deposited: 29/06/2020
ISSN (print): 1079-5006
ISSN (electronic): 1758-535X
Publisher: Oxford University Press
PubMed id: 25123647
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