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Lookup NU author(s): Sadaf Iqbal, Dr Abdul ChaudhryORCiD
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© The Author(s) 2020. Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can ameliorate NPs-associated pathophysiologies. The present study examined Cinnamomum cassia (C. cassia) bark extracts (CMBE) for its ameliorative activity against Ni-NPs-induced pathophysiological and histopathological alterations in male Sprague Dawley rats. The biochemical analyses revealed that dosing rats with Ni-NPs at 10 mg/kg/body weight (b.w.) significantly altered the normal structural and biochemical adaptations in the liver and kidney. Conversely, supplementations with CMBE at different doses (225, 200, and 175 mg/kg/b.w. of rat) ameliorated the altered blood biochemistry and reduced the biomarkers of liver and kidney function considerably (p < 0.05) in a dose-dependent manner. However, the best results were at 225 mg/kg/b.w. of rat. The study provided preliminary information about the protective effect of C. cassia against Ni-NPs indicated liver and kidney damages. Future investigations are needed to explore C. cassia mechanism of action of C. cassia and isolation of single constituents of C. cassia to assess their pharmaceutical importance accordingly.
Author(s): Iqbal S, Jabeen F, Peng C, Ijaz MU, Chaudhry AS
Publication type: Article
Publication status: Published
Journal: Human and Experimental Toxicology
Year: 2020
Volume: 39
Issue: 11
Pages: 1565-1581
Print publication date: 01/11/2020
Online publication date: 23/06/2020
Acceptance date: 02/04/2018
ISSN (print): 0960-3271
ISSN (electronic): 1477-0903
Publisher: Sage Publications Ltd
URL: https://doi.org/10.1177/0960327120930125
DOI: 10.1177/0960327120930125
PubMed id: 32573270
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