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Lookup NU author(s): Professor Akane Kawamura
This is the authors' accepted manuscript of a book chapter that has been published in its final definitive form by Springer International Publishing, 2020.
For re-use rights please refer to the publisher's terms and conditions.
Histone demethylases (KDMs) catalyse the removal of N-methyl marks on histones and play important roles in epigenetic regulation. Abnormal histone methylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as promising therapeutic targets. This chapter provides an overview of JmjC-domain-containing KDMs (JmjC-KDMs), with a particular focus on recent advances in JmjC-KDM inhibitor development from a structural perspective.
Author(s): Wright M, Brennan P, Kawamura A
Editor(s): Antonello Mai
Publication type: Book Chapter
Publication status: Published
Book Title: Chemical Epigenetics
Year: 2020
Volume: 33
Pages: 221-253
Print publication date: 15/01/2020
Online publication date: 14/01/2020
Acceptance date: 01/07/2019
Series Title: Topics in Medicinal Chemistry
Publisher: Springer International Publishing
Place Published: Cham
URL: https://doi.org/10.1007/7355_2019_75
DOI: 10.1007/7355_2019_75
Notes: 9783030429812 Hardback ISBN
Library holdings: Search Newcastle University Library for this item
ISBN: 9783030429829
