Browse by author
Lookup NU author(s): Sanjay PandanaboyanaORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2015 Elsevier Inc. All rights reserved.Introduction This meta-analysis aimed to review the percentage increase in future liver remnant (FLR) and perioperative outcomes after portal vein ligation (PVL) and portal vein embolization (PVE) before liver resection. Methods An electronic search was performed of the MEDLINE, EMBASE, and PubMed databases using both subject headings (MeSH) and truncated word searches to identify all articles published that related to this topic. Pooled risk ratios were calculated for categorical outcomes and mean differences for secondary continuous outcomes using the fixed-effects and random-effects models for meta-analysis. Results Seven studies involving 218 patients met the inclusion criteria. There was no difference in the increase in FLR between the 2 groups 39% (PVE) versus 27% (PVL; mean difference [MD] 6.04; 95% CI, -0.23, 12.32; Z = 1.89; P =.06). Similarly, there was no difference in the morbidity (risk ratio [RR], 1.08; 95% CI, 0.55, 2.09; Z = 0.21; P =.83) and mortality (RR, 0.87; 95% CI, 0.19, 3.92; Z = 0.18; P =.85) in the 2 groups after liver resection. While awaiting liver resection after PVL and PVE, no difference was noted in the number of patients developing disease progression (RR, 0.93; 95% CI, 0.52, 1.66; Z = 0.24; P =.81). In a subset analysis comparing FLR with PVE and PVL as part of the procedure called an associating liver partition with PVL for staged hepatectomy (ALPPS), there was a significant increase in FLR in favor of ALPPS (MD, -17.09; 95% CI, -32.78, -1.40; Z = 2.14; P =.03). Conclusion PVL and PVE result in comparable percentage increase in FLR with similar morbidity and mortality rates. The ALPPS procedure results in an improved percentage increase in FLR compared with PVE alone.
Author(s): Pandanaboyana S, Bell R, Hidalgo E, Toogood G, Prasad KR, Bartlett A, Lodge JP
Publication type: Article
Publication status: Published
Journal: Surgery
Year: 2015
Volume: 157
Issue: 4
Pages: 690-698
Print publication date: 01/04/2015
Online publication date: 20/02/2015
Acceptance date: 12/12/2014
ISSN (print): 0039-6060
ISSN (electronic): 1532-7361
Publisher: Mosby Inc.
URL: https://doi.org/10.1016/j.surg.2014.12.009
DOI: 10.1016/j.surg.2014.12.009
PubMed id: 25704417
Altmetrics provided by Altmetric
