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Subjective Cognitive Complaints Given in Questionnaire: Relationship With Brain Structure, Cognitive Performance and Self-Reported Depressive Symptoms in a 25-Year Retrospective Cohort Study

Lookup NU author(s): Dr Charlotte Allan

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Abstract

© 2020Background: Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms. Method: 800 community-dwelling older adults were drawn from the Whitehall II cohort. Subjective cognitive complaint inquiry for memory and concentration, a range of neuropsychological tests and multimodal MRI were performed in 2012–2016. Subjective complaints were again elicited after 1 year. Group differences in grey and white matter, between those with and without subjective complaints, were assessed using voxel-based morphometry and tract-based spatial statistics, respectively. Mixed effects models assessed whether cognitive decline or depressive symptoms (over a 25-year period) were associated with later subjective complaints. Analyses were controlled for potential confounders and multiple comparisons. Results: Mean age of the sample at scanning was 69.8 years (±5.1, range: 60.3–84.6). Subjective memory complaints were common (41%) and predicted further similar complaints later (mean 1.4 ± 1.4 years). There were no group differences in grey matter density or white matter integrity. Subjective complaints were not cross-sectionally or longitudinally associated with objectively assessed cognition. However, those with subjective complaints reported higher depressive symptoms (“poor concentration”: odds ratio = 1.12, 95% CI 1.07–1.18; “poor memory”: odds ratio = 1.18, 1.12–1.24). Conclusions: In our sample subjective complaints were consistent over time and reflected depressive symptoms but not markers of neurodegenerative brain damage or concurrent or future objective cognitive impairment. Clinicians assessing patients presenting with memory complaints should be vigilant for affective disorders. These results question the rationale for including subjective complaints in a spectrum with Mild Cognitive Impairment diagnostic criteria.


Publication metadata

Author(s): Topiwala A, Suri S, Allan C, Zsoldos E, Filippini N, Sexton CE, Mahmood A, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP

Publication type: Article

Publication status: Published

Journal: American Journal of Geriatric Psychiatry

Year: 2020

Pages: epub ahead of print

Online publication date: 07/07/2020

Acceptance date: 02/07/2020

ISSN (print): 1064-7481

ISSN (electronic): 1545-7214

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.jagp.2020.07.002

DOI: 10.1016/j.jagp.2020.07.002


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