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For the sake of the Bioeconomy: define what a Synthetic Biology Chassis is!

Lookup NU author(s): Professor Natalio Krasnogor

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Abstract

© 2020 Elsevier B.V.At the onset of the 4th Industrial Revolution, the role of synthetic biology (SynBio) as a fuel for the bioeconomy requires clarification of the terms typically adopted by this growing scientific-technical field. The concept of the chassis as a defined, reusable biological frame where non-native components can be plugged in and out to create new functionalities lies at the boundary between frontline bioengineering and more traditional recombinant DNA technology. As synthetic biology leaves academic laboratories and starts penetrating industrial and environmental realms regulatory agencies demand clear definitions and descriptions of SynBio constituents, processes and products. In this article, the state of the ongoing discussion on what is a chassis is reviewed, a non-equivocal nomenclature for the jargon used is proposed and objective criteria are recommended for distinguishing SynBio agents from traditional GMOs. The use of genomic barcodes as unique identifiers is strongly advocated. Finally the soil bacterium Pseudomonas putida is shown as an example of the roadmap that one environmental isolate may go through to become a bona fide SynBio chassis,


Publication metadata

Author(s): de Lorenzo V, Krasnogor N, Schmidt M

Publication type: Article

Publication status: Published

Journal: New Biotechnology

Year: 2021

Volume: 60

Pages: 44-51

Print publication date: 25/01/2021

Online publication date: 02/09/2020

Acceptance date: 02/04/2016

ISSN (print): 1871-6784

ISSN (electronic): 1876-4347

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.nbt.2020.08.004

DOI: 10.1016/j.nbt.2020.08.004

PubMed id: 32889152


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