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Lookup NU author(s): Professor Michael TaggartORCiD
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IEEEThe relatively limited understanding of the physiology of uterine activation prevents us from achieving optimal clinical outcomes for managing serious pregnancy disorders such as preterm birth or uterine dystocia. There is increasing awareness that multi-scale computational modeling of the uterus is a promising approach for providing a qualitative and quantitative description of uterine physiology. The overarching objective of such approach is to coalesce previously fragmentary information into a predictive and testable model of uterine activity that, in turn, informs the development of new diagnostic and therapeutic approaches to these pressing clinical problems. This article assesses current progress towards this goal. We summarize the electrophysiological basis of uterine activation as presently understood and review recent research approaches to uterine modeling at different scales from single cell to tissue, whole organ and organism with particular focus on transformative data in the last decade. We describe the positives and limitations of these approaches, thereby identifying key gaps in our knowledge on which to focus, in parallel, future computational and biological research efforts.
Author(s): Xu Y, Liu H, Hao D, Taggart M, Zheng D
Publication type: Article
Publication status: Published
Journal: IEEE Reviews in Biomedical Engineering
Year: 2020
Volume: 15
Pages: 341-353
Online publication date: 11/09/2020
Acceptance date: 02/04/2016
ISSN (print): 1937-3333
ISSN (electronic): 1941-1189
Publisher: Institute of Electrical and Electronics Engineers
URL: https://doi.org/10.1109/RBME.2020.3023535
DOI: 10.1109/RBME.2020.3023535
PubMed id: 32915747
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