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Lookup NU author(s): Emeritus Professor Nick Europe-Finner
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© The Author(s) 2020.This article on clinical trial design incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s (PVRI) Innovative Drug Development Initiative (IDDI) as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertension. It is increasingly clear that the design of phase 2 and 3 trials in pulmonary hypertension will have to diversify from the traditional randomised double-blind design, given the anticipated need to trial novel therapeutic approaches in the immediate future. This article reviews a wide range of differing approaches and places these into context within the field of pulmonary hypertension.
Author(s): Nikkho S, Fernandes P, White RJ, Deng C, Farber HW, Corris PA
Publication type: Article
Publication status: Published
Journal: Pulmonary Circulation
Year: 2020
Volume: 10
Issue: 4
Online publication date: 20/07/2020
Acceptance date: 17/06/2020
ISSN (print): 2045-8932
ISSN (electronic): 2045-8940
Publisher: Sage Publications Ltd
URL: https://doi.org/10.1177/2045894020941491
DOI: 10.1177/2045894020941491
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