Browse by author
Lookup NU author(s): Dr Hans Sathasivam, Professor Philip Sloan, Professor Peter Thomson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons LtdBackground: Oral potentially malignant disorders are a clinical conundrum as there are no reliable methods to predict their behaviour. We combine conventional oral epithelial dysplasia grading with DNA ploidy analysis to examine the validity of this approach to risk assessment in a cohort of patients with known clinical outcomes. Methods: Sections from diagnostic biopsies were assessed for oral epithelial dysplasia using the WHO grading system, and DNA ploidy analysis was performed using established methods. Patients reviewed for a minimum of 5 years who did not develop oral squamous cell carcinoma were classified as “non-transforming” cases. Patients that developed oral squamous cell carcinoma ≥ 6 months after the initial diagnostic biopsy were classified as having “malignant transformation.”. Results: Ninety cases were included in the study. Seventy cases yielded informative DNA ploidy results. Of these 70 cases, 31 progressed to cancer. Oral epithelial dysplasia grading and DNA ploidy status were both significantly associated with clinical outcome (P < 0.05). Severe dysplasia had a hazard ratio of 3.50 (CI: 1.46, 8.45; P = 0.005) compared to cases with mild dysplasia. Aneuploidy had a hazard ratio of 2.09 (CI: 1.01, 4.32; P = 0.046) compared to cases with a diploid/tetraploid status. Receiver operating characteristic analysis gave an area under the curve of 0.617 for DNA ploidy status and 0.688 when DNA ploidy status was combined with dysplasia grading. Conclusion: Our findings suggest that combining dysplasia grading with DNA ploidy status has clinical utility which could be used to develop novel management algorithms.
Author(s): Sathasivam HP, Nayar D, Sloan P, Thomson PJ, Odell EW, Robinson M
Publication type: Article
Publication status: Published
Journal: Journal of Oral Pathology and Medicine
Year: 2020
Volume: 50
Issue: 2
Pages: 200-209
Print publication date: 01/02/2021
Online publication date: 05/11/2020
Acceptance date: 12/09/2020
ISSN (print): 0904-2512
ISSN (electronic): 1600-0714
Publisher: Blackwell Publishing Ltd
URL: https://doi.org/10.1111/jop.13121
DOI: 10.1111/jop.13121
PubMed id: 33151583
Altmetrics provided by Altmetric
