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The maturation of DNA encoded libraries: opportunities for new users

Lookup NU author(s): James Hunter, Professor Mike Waring

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Abstract

DNA-encoded combinatorial libraries (DECLs) represent an exciting new technology for high-throughput screening, significantly increasing its capacity and cost-effectiveness. Historically, DECLs have been the domain of specialized academic groups and industry; however, there has recently been a shift toward more drug discovery academic centers and institutes adopting this technology. Key to this development has been the simplification, characterization and standardization of various DECL subprotocols, such as library design, affinity screening and data analysis of hits. This review examines the feasibility of implementing DECL screening technology as a first-time user, particularly in academia, exploring the some important considerations for this, and outlines some applications of the technology that academia could contribute to the field.

Publication metadata

Author(s): Conole D, Hunter JH, Waring MJ

Publication type: Article

Publication status: Published

Journal: Future Medicinal Chemistry

Year: 2021

Volume: 13

Pages: 173

Print publication date: 01/01/2021

Online publication date: 04/12/2020

Acceptance date: 05/11/2020

ISSN (print): 1756-8919

ISSN (electronic): 1756-8927

Publisher: Newlands Press

URL: https://doi.org/10.4155/fmc-2020-0285

DOI: 10.4155/fmc-2020-0285

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