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Homo-PROTACs: Bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Lookup NU author(s): Dr Chiara ManiaciORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Publication metadata

Author(s): Maniaci C, Hughes SJ, Testa A, Chen W, Lamont DJ, Rocha S, Alessi DR, Romeo R, Ciulli A

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2017

Volume: 8

Online publication date: 10/10/2017

Acceptance date: 01/08/2017

Date deposited: 22/02/2021

ISSN (electronic): 2041-1723

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/s41467-017-00954-1

DOI: 10.1038/s41467-017-00954-1

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Funding

Funder referenceFunder name
European Research Council (ERC-2012-StG-311460 DrugE3CRLs Starting Grant to A.C.)
Italian Ministry of Education, University and Research (Miur, PhD Studentship to C.M.)
Medical Research Council (MRC, grant number MC_UU_12016/2 to D.R.A.)
S.R. is funded by a CRUK Senior Fellowship (C99667/A12918).
Wellcome Trust (Strategic Award 100476/Z/12/Z for biophysics and drug discovery to the Division of Biological Chemistry and Drug Discovery)

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