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Canine thyroid carcinoma prognosis following the utilisation of computed tomography assisted staging

Lookup NU author(s): Professor Stephen Rushton

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Abstract

© 2021 British Veterinary AssociationBackground: Metastatic disease is frequently present at the time of diagnosis of canine thyroid carcinoma; however, utilisation of computed tomography (CT) alone for staging pre-treatment has been rarely reported in the veterinary literature. Methods: The aims of this retrospective study were to stage affected dogs using CT findings of the cervical and thoracic regions, combined with histopathology/cytology results, in order to assess whether metastatic disease/WHO staging was of prognostic significance. Results: Fifty-eight dogs were included in the study. Classification of cases into WHO stages I, II, III and IV were 10%, 50%, 9% and 31%, respectively. No statistically significant effect of WHO stage classification on overall survival/follow-up time was found (P =.576). Surgery resulted in a statistically significant increase in overall survival/follow-up time (P <.01). There was no statistically significant effect on overall survival/follow-up time in dogs that received medical therapy, either as sole therapy or as an adjunctive post-surgery (P =.198). Conclusion: In summary, this study documents the metastatic rate of canine thyroid carcinoma using CT for staging pre-treatment. Staging utilising CT revealed a higher distant metastatic rate in dogs with thyroid carcinoma when compared to historical studies using different imaging techniques. As long-term outcomes are possible for cases with advanced disease, surgical intervention could still be considered.


Publication metadata

Author(s): Giannasi C, Rushton S, Rook A, Steen NVD, Venier F, Ward P, Bell R, Trevail T, Lamb V, Eiras A, Ellis J, Roberts E

Publication type: Article

Publication status: Published

Journal: Veterinary Record

Year: 2021

Pages: epub ahead of print

Online publication date: 07/02/2021

Acceptance date: 03/12/2020

ISSN (print): 0042-4900

ISSN (electronic): 2042-7670

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/vetr.55

DOI: 10.1002/vetr.55


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