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Lookup NU author(s): Dr Nik Murphy, Dr Alison Killen, Dr Sara Graziadio, Professor Lynn RochesterORCiD, Dr Michael FirbankORCiD, Professor Mark BakerORCiD, Dr Charlotte Allan, Daniel Collerton, Professor John-Paul TaylorORCiD, Dr Prabitha Urwyler
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© Copyright © 2021 Murphy, Killen, Gupta, Graziadio, Rochester, Firbank, Baker, Allan, Collerton, Taylor and Urwyler.Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear although visual evoked potential (VEP) differences have been associated with VH at an earlier stage of PD. Here we compared the amplitude and latency pattern reversal VEPs in healthy controls (n = 21) and PDD patients (n = 34) with a range of VH severities. PDD patients showed increased N2 latency relative to controls, but no significant differences in VEP measures were found for patients reporting complex VH (CVH) (n = 17) compared to those without VH. Our VEP findings support previous reports of declining visual system physiology in PDD and some evidence of visual system differences between patients with and without VH. However, we did not replicate previous findings of a major relationship (Formula presented.) between the integrity of the visual pathway and VH.
Author(s): Murphy N, Killen A, Gupta RK, Graziadio S, Rochester L, Firbank M, Baker MR, Allan C, Collerton D, Taylor J-P, Urwyler P
Publication type: Article
Publication status: Published
Journal: Frontiers in Neurology
Year: 2021
Volume: 11
Online publication date: 28/01/2021
Acceptance date: 31/12/2020
Date deposited: 19/03/2021
ISSN (electronic): 1664-2295
Publisher: Frontiers Media S.A.
URL: https://doi.org/10.3389/fneur.2020.579113
DOI: 10.3389/fneur.2020.579113
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