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Hippocampal hub neurons maintain distinct connectivity throughout their lifetime

Lookup NU author(s): Dr Marco BocchioORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

The temporal embryonic origins of cortical GABA neurons are critical for their specialization. In the neonatal hippocampus, GABA cells born the earliest (ebGABAs) operate as ‘hubs’ by orchestrating population synchrony. However, their adult fate remains largely unknown. To fill this gap, we have examined CA1 ebGABAs using a combination of electrophysiology, neurochemical analysis, optogenetic connectivity mapping as well as ex vivo and in vivo calcium imaging. We show that CA1 ebGABAs not only operate as hubs during development, but also maintain distinct morpho-physiological and connectivity profiles, including a bias for long-range targets and local excitatory inputs. In vivo, ebGABAs are activated during locomotion, correlate with CA1 cell assemblies and display high functional connectivity. Hence, ebGABAs are specified from birth to ensure unique functions throughout their lifetime. In the adult brain, this may take the form of a long-range hub role through the coordination of cell assemblies across distant regions.

Publication metadata

Author(s): Bocchio M, Gouny C, Angulo-Garcia D, Toulat T, Tressard T, Quiroli E, Baude A, Cossart R

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2020

Volume: 11

Online publication date: 11/09/2020

Acceptance date: 20/08/2020

Date deposited: 04/05/2021

ISSN (electronic): 2041-1723

Publisher: Nature

URL: https://doi.org/10.1038/s41467-020-18432-6

DOI: 10.1038/s41467-020-18432-6

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