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The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

Lookup NU author(s): Professor Anthony De SoyzaORCiD

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Abstract

Copyright © 2021 Elsevier Ltd. All rights reserved.Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.


Publication metadata

Author(s): Adeloye D, Elneima O, Daines L, Poinasamy K, Quint JK, Walker S, Brightling CE, Siddiqui S, Hurst JR, Chalmers JD, Pfeffer PE, Novotny P, Drake TM, Heaney LG, Rudan I, Sheikh A, De Soyza A

Publication type: Review

Publication status: Published

Journal: The Lancet Respiratory Medicine

Year: 2021

Volume: 9

Issue: 12

Pages: 1467-1478

Print publication date: 01/12/2021

Online publication date: 17/12/2021

Acceptance date: 02/04/2018

ISSN (electronic): 2213-2600

Publisher: NLM (Medline)

URL: https://doi.org/10.1016/S2213-2600(21)00286-1

DOI: 10.1016/S2213-2600(21)00286-1

PubMed id: 34416191


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