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Lookup NU author(s): Professor Vijay KunadianORCiD
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© 2022 American College of Cardiology Foundation. Biological and sociocultural differences between men and women are complex and likely account for most of the variations in the epidemiology and treatment outcomes of coronary artery disease (CAD) between the 2 sexes. Worse outcomes in women have been described following both conservative and invasive treatments of CAD. For example, increased levels of residual platelet reactivity during treatment with antiplatelet drugs, higher rates of adverse cardiovascular outcomes following percutaneous coronary revascularization, and higher operative and long-term mortality after coronary bypass surgery have been reported in women compared with in men. Despite the growing recognition of sex-specific determinants of outcomes, representation of women in clinical studies remains low and sex-specific management strategies are generally not provided in guidelines. This review summarizes the current evidence on sex-related differences in patients with CAD, focusing on the differential outcomes following medical therapy, percutaneous coronary interventions, and coronary artery bypass surgery.
Author(s): Gaudino M, Di Franco A, Cao D, Giustino G, Bairey Merz CN, Fremes SE, Kirtane AJ, Kunadian V, Lawton JS, Masterson Creber RM, Sandner S, Vogel B, Zwischenberger BA, Dangas GD, Mehran R
Publication type: Review
Publication status: Published
Journal: Journal of the American College of Cardiology
Year: 2022
Volume: 79
Issue: 14
Pages: 1407-1425
Print publication date: 12/04/2022
Online publication date: 04/04/2022
Acceptance date: 12/07/2021
ISSN (print): 0735-1097
ISSN (electronic): 1558-3597
Publisher: Elsevier Inc.
URL: https://doi.org/10.1016/j.jacc.2021.07.066
DOI: 10.1016/j.jacc.2021.07.066
