Browse by author
Lookup NU author(s): Issac Goh, Dr Laura JardineORCiD, Dr Rachel Botting, Dr Emily StephensonORCiD, Justin Engelbert, Rasa Elmentaite, Mohi Miah, Dave Horsfall, Professor Muzlifah Haniffa
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Copyright © 2022 the authors. Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.
Author(s): Suo C, Dann E, Goh I, Jardine L, Kleshchevnikov V, Park J-E, Botting RA, Stephenson E, Engelbert J, Tuong ZK, Polanski K, Yayon N, Xu C, Suchanek O, Elmentaite R, Conde CD, He P, Pritchard S, Miah M, Moldovan C, Steemers AS, Mazin P, Prete M, Horsfall D, Marioni JC, Clatworthy MR, Haniffa M, Teichmann SA
Publication type: Article
Publication status: Published
Journal: Science
Year: 2022
Volume: 376
Issue: 6597
Print publication date: 03/06/2022
Online publication date: 12/05/2022
Acceptance date: 02/05/2022
ISSN (print): 0036-8075
ISSN (electronic): 1095-9203
Publisher: American Association for the Advancement of Science
URL: https://doi.org/10.1126/science.abo0510
DOI: 10.1126/science.abo0510
PubMed id: 35549310
Altmetrics provided by Altmetric
