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Lookup NU author(s): ISHA Karnik, Rachel Telfer-Sutherland, Dr Joanna Elson, Sebastian Aspinall, Dr Annette Meeson
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© 2022 Elsevier B.V.Thyroid cancer (TC) is a common endocrine cancer with a rising incidence. Current treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the processes that cause disease progression. In this review, we provide insight into TGF-β driven epithelial to mesenchymal transition (EMT), summarizing the current literature surrounding thyroid carcinogenesis, and discuss the potential for therapeutic strategies targeting the TGF-β signalling pathway. Understanding the underlying mechanisms that regulate cancer stem cell (CSC) growth and TGF-β signalling may provide novel therapeutic approaches for highly resistant TCs.
Author(s): Karnik I, Sutherland R, Elson J, Aspinall S, Meeson A
Publication type: Review
Publication status: Published
Journal: Biochimica et Biophysica Acta - Reviews on Cancer
Year: 2022
Volume: 1877
Issue: 4
Print publication date: 01/07/2022
Online publication date: 18/06/2022
Acceptance date: 14/06/2022
ISSN (print): 0304-419X
ISSN (electronic): 1879-2561
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.bbcan.2022.188752
DOI: 10.1016/j.bbcan.2022.188752
PubMed id: 35728736
